期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 181, 期 3, 页码 237-240出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2009.10.010
关键词
Schizophrenia; P-31 Magnetic Resonance Spectroscopy; High energy phosphates
资金
- Indo-US [1 R43 04370-01A1]
We reported increased high-energy phosphate metabolism in the basal ganglia of antipsychotic-naive schizophrenia patients using P-31 Magnetic Resonance Spectroscopy (MRS). These patients were followed up for 1 year and and reassessed using P-31 MRS. Fourteen (8 males) patients with DSM-IV schizophrenia and 14 (11 males) healthy controls underwent P-31 MRS of sub-cortical structures (predominantly basal ganglia) twice (mean +/- S.D. interscan interval 1.15 +/- 0.17 year) on a 1.5 T scanner. Total scores on the Positive and Negative Syndrome Scale (PANSS) decreased significantly after treatment in schizophrenia patients. Patients had significantly lower mean PCr/ATP ratios than healthy controls at baseline but not during the follow-up. In patients, there was a significant positive correlation between the magnitude of improvement in PANSS total scores and the extent of change in the PCr/ATP ratio. Findings support the hypothesis that reduction of energy demand or induction of decreased energy-demanding processes might underlie the mechanism of action of antipsychotics in schizophrenia. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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