期刊
ARABIAN JOURNAL OF CHEMISTRY
卷 8, 期 5, 页码 715-719出版社
ELSEVIER
DOI: 10.1016/j.arabjc.2011.11.008
关键词
Anti-inflammatory; Analgesic; Benzimidazole
A novel series of 2-substituted benzimidazole derivatives (3a-3j) were synthesized by the reaction of 2-chloro methyl benzimidazole with substituted primary aromatic amines. All the compounds were characterized by UV, IR, H-1 NMR, mass spectral data and CHN elemental analysis. The synthesized derivatives were screened for analgesic and anti-inflammatory activities. All the compounds showed significant effect at 100 mg/kg p.o. and the experimental data are statistically significant at p < 0.01 level. (C) 2011 Production and hosting by Elsevier B.V. on behalf of King Saud University.
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