期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 173, 期 1, 页码 59-62出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2008.12.005
关键词
Functional MRI; Skin conductance responses; Oddball; Anterior cingulate; PTSD; Arousal
资金
- NHMRC Program [300304]
- Australian Research Council Linkage [LP0212048]
- NHMRC Australian Clinical Research Fellowship [358676]
- NHMRC Biomedical Research Fellowship [358770]
- Australian Research Council [LP0212048] Funding Source: Australian Research Council
Reduced ventral anterior cingulate (vACC) activity to threat is thought to reflect an impairment in regulating arousal networks in posttraumatic stress disorder (PTSD). Concurrent functional magnetic resonance imaging (fMRI) and skin conductance response (SCR) recording were used to examine neural functioning when arousal networks are engaged. Eleven participants with PTSD and 11 age- and sex-matched non-traumatized controls performed an oddball task that required responding to salient, non-trauma-related auditory target tones embedded in lower frequency background tones. Averaged target-background analyses revealed significantly greater dorsal ACC, supramarginal gyrus, and hippocampal activity in PTSD relative to control participants. With-SCR target responses resulted in increased vACC activity in controls, and dorsal ACC activity in PTSD. PTSD participants had reduced vACC activity relative to controls to target tones when SCR responses were present. This reduction in vACC in MD relative to controls was not apparent in without-SCR responses. These findings suggest that a reduction in vACC in PTSD occurs specifically when arousal networks are engaged. (C) 2009 Elsevier Ireland Ltd. All rights reserved
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