期刊
PSYCHIATRY RESEARCH
卷 219, 期 1, 页码 221-224出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2014.05.021
关键词
Catechol-O-Methyltransferase Val158Met polymorphism; Electroencephalographic alpha peak frequency; Major depressive disorder
类别
资金
- BRAINnet under the governance of the BRAINnet foundation
This study could not confirm the association between the Catechol-O-Methyltransferase Val158Met polymorphism (COMT) and electroencephalographic (EEG) alpha peak frequency (APF) in two independent cohorts of 187 (96 depressed and 91 healthy participants) and 413 healthy participants. If COMT and APF play a role in depression or antidepressant treatment response, they do not have a shared pathway. We emphasize the importance of publishing null-findings for obtaining more accurate overall estimates of genetic effects. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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