期刊
PSYCHIATRY RESEARCH
卷 207, 期 1-2, 页码 13-18出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2013.02.026
关键词
AMPA receptor; Glutamate; Bipolar disorder; Genetic association; Polymorphism
类别
资金
- National Basic Research Program of China [2011CB707805]
- National Science and Technology Project [2012BAI01B06]
- National Natural Science Foundation of China [81222017, 91232305]
Myosin Vb (MYO5B) has recently been implicated in the etiology of bipolar disorder in a genome-wide association study (GWAS). This gene is involved in amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit glutamate receptor 1 (GluR1) recycling and plays an important role in the primary excitatory neurotransmission. Dysfunction of the brain glutamate system has been postulated to be involved in the pathophysiology in schizophrenia. To further investigate the association between MYO5B polymorphisms and schizophrenia, we genotyped nine single nucleotide polymorphisms (SNPs) in an independent sample of 1463 individuals with schizophrenia and 1563 healthy control subjects, and detected three SNPs and two haplotype blocks which displayed significant association with schizophrenia. This association was further strengthened by the results of meta-analysis. Our data strongly supported that the MYO5B gene might be associated with schizophrenia in the Chinese Han population and they have implications for understanding the glutamate hypothesis of schizophrenia. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
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