期刊
PSYCHIATRY RESEARCH
卷 196, 期 1, 页码 9-14出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2011.09.011
关键词
Cigarette smoking; Anhedonia; Reward responsiveness
类别
资金
- VA Center Grant
- NIMH [R01 MH68376, R21 MH078979]
- VA Merit Award
- VA Career Development Award
- Advanced Neuro Technology (ANT)
- AstraZeneca
Cigarette smoking rates remain remarkably high in schizophrenia relative to smoking in other psychiatric groups. Impairments in the reward system may be related to elevated rates of nicotine dependence and lower cessation rates in this psychiatric group. Smokers with schizophrenia and schizoaffective disorder (SWS; n = 15; M-age = 54.87, S.D. = 6.51, 100% male) and a non-psychiatric control group of smokers (NCL; n = 16; M-age = 50.38, S.D. = 11.52; 93.8% male) were administered a computerized signal detection task to measure reward-based learning. Performance on the signal detection task was assessed by response bias, discriminability, reaction time, and hit rate. Clinician-assessed and self-reported measures of smoking and psychiatric symptoms were completed. SWS exhibited similar patterns of reward-based learning compared to control smokers. However, decreased reward-based learning was associated with increased levels of nicotine dependence in SWS, but not among control smokers. Nicotine withdrawal and urge to smoke were correlated with anhedonia within the SWS group. Among SWS, reduced reward responsiveness and increased anhedonia were associated with and may contribute to greater co-occurring nicotine dependence. These findings emphasize the importance of targeting reward system functioning in smoking cessation treatment for individuals with schizophrenia. Published by Elsevier Ireland Ltd.
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