期刊
PSYCHIATRY RESEARCH
卷 198, 期 1, 页码 39-46出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2011.08.022
关键词
CREB1; CREBBP; CREM; Major depressive disorder; Bipolar disorder
类别
资金
- Medical Research Center, Korea Science and Engineering Foundation, Republic of Korea [R13-2002-005-04001-0]
- Korean Health 21 R & D Project, Ministry of Health and Welfare, Republic of Korea [A050047]
Some evidence suggests an association between genetic variants within the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), CREB binding protein (CREBBP) and cAMP response element-modulator (CREM) and several psychiatric disorders. The present study investigated whether some single nucleotide polymorphisms (SNPs) within these genes could be associated with major depressive disorder (MDD) and bipolar disorder (BD) and whether they could predict clinical outcomes in Korean inpatients treated with antidepressants and mood stabilizers, respectively. The sample comprised 145 patients with MDD, 132 patients with BD and 170 psychiatrically healthy controls. Participants were genotyped for 14 SNPs within CREB1, CREBBP and CREM. Baseline and final clinical measures, including the Montgomery-Asberg Depression Rating Scale and Young Mania Rating Scale for patients with MDD and BD, respectively, were recorded. All p-values were 2-tailed, and statistical significance was conservatively set at the 0.006 level in order to reduce the likelihood of false positive results. We failed to observe any association of the 14 SNPs genotypes or alleles with clinical improvement, response and remission rates as well as final outcomes in any of such disorders. Our findings suggest that the 14 SNP under investigation in our study do not influence diagnosis and treatment response in patients with MDD and BD. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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