期刊
PSYCHIATRY RESEARCH
卷 190, 期 2-3, 页码 221-225出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2011.06.024
关键词
Mental health; Vitamin D; Epidemiology; Cross-sectional studies; Norway
类别
资金
- Northern Norway Regional Health Authority
Observational and intervention studies have suggested an association between low levels of 25-hydroxyvitamin D (25(OH)D) and depressive symptoms in several subgroups of disease and age. This study tests the hypothesis in a general population. Our data are based on 10,086 persons who participated in the sixth Tromso study carried out in 2007-2008. Depressive symptoms were evaluated using the Hopkins Symptoms Check List 10 (SCL-10) based on answers from a questionnaire. Results were adjusted for known confounders such as age, gender, body-mass index, physical exercise, alcohol, education, marital status, kidney function and chronic disease. Results are presented for smokers (N=1966) and non-smokers (N=8120) separately as our immunoassay seems to overestimate 25(OH)D levels for smokers. Low serum 25 (OH)D levels were found to be a significant predictor of depressive symptoms in both smokers and non-smokers. The association seemed to be stronger in women. The odds ratios for depression in the highest 25 (OH)D quartile were 0.59 (0.39-0.89) in smokers and 0.74 (0.58-0.95) in non-smokers compared with the lowest quartile. However, no conclusions with regard to causality can be drawn due to the cross-sectional design of the study. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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