期刊
PSYCHIATRIC GENETICS
卷 23, 期 1, 页码 29-32出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/YPG.0b013e32835862c5
关键词
Han Chinese; NDUFS7; schizophrenia; tagging single-nucleotide polymorphism
资金
- National Natural Science Foundation of China [30900486, 31000557]
- Yunnan Province [2009CI119]
Accumulating evidence suggests that mitochondrial dysfunction contributes toward the pathogenesis of psychiatric diseases. NADH dehydrogenase Fe-S protein 7 (NDUFS7), a subunit of respiratory chain complex I, has been reported recently to be associated with bipolar disorder. To test whether this gene can confer a wide variety of psychiatric disorders, we carried out a case-control association analysis of three tagging single-nucleotide polymorphisms (rs2074896, rs2074897, and rs2074898) in the NDUFS7 gene by sequencing 330 Han Chinese patients with schizophrenia and 330 well-matched healthy controls. We found no significant difference in the frequency distributions of alleles, genotypes, and haplotypes between the cases and the controls, indicating no active role of this gene in schizophrenia. Psychiatr Genet 23:29-32 (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. Psychiatric Genetics 2013, 23:29-32
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