Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power

A recent study in a sample of Plains Indians showed association between eight single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and resting theta electroencephalogram (EEG) power. This association appeared to generalize to alcohol use disorders, for which EEG power is a potential endophenotype. We analyzed a large, diverse sample for replication of the association of these implicated SGIP1 SNPs (genotyped on the Illumina 1M platform) with alcohol dependence (N = 3988) and theta EEG power (N = 1066). We found no evidence of association of the earlier implicated SGIP1 SNPs with either alcohol dependence or theta EEG power (all P > 0.15) in this sample. The earlier implicated SNPs located in SGIP1 gene showed no association with alcohol dependence or theta EEG power in this sample of individuals with European and/or African ancestry. This failure to replicate may be the result of differences in ancestry between this sample and the original sample. Psychiatr Genet 21:265-266 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.