期刊
PROTEOMICS CLINICAL APPLICATIONS
卷 4, 期 4, 页码 407-415出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/prca.200900123
关键词
Exosomes; Microparticles; Microvesicles; Plasma; Sub-cellular
资金
- Fondo de Investigaciones Sanitarias (Instituto de Salud Carlos III) [06/0621]
- Spanish Ministry
- PN I + D SAF [PN I + D SAF 2005-00855]
- NIH [AT-1576]
- HEPA DIP consortium
- BBVA foundation
In the recent years, global proteomics approaches have been widely used to characterize a number of tissue proteomes including plasma and liver; however, the elevated complexity of these samples in combination with the high abundance of some specific proteins make the study of the lowest abundant proteins difficult. This review is focused on different strategies that have been developed to extend the proteome focused on these two tissues, as, for example, the analysis of sub-cellular proteomes. In this regard, two special kind of extracellular vesicles exosomes and membrane plasma shedding vesicles are emerging as excellent biological source both to extend the liver and plasma proteomes and to be applied in the discovery of non-invasive liver-specific disease biomarkers.
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