期刊
PROTEOMICS CLINICAL APPLICATIONS
卷 4, 期 4, 页码 372-378出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/prca.200900151
关键词
Glycosylation; Liver diseases; N-glycome
The study of the total serum N-glycome during liver cirrhosis has demonstrated numerous alterations. The identification of the glycoproteins carrying these modifications and their relative contribution to the modification of the total serum N-glycome has shown the important role of IgA and IgG. The possible mechanisms of glycosylation alteration of the Igs and of liver secreted glycoproteins, the consequences in the pathophysiology of cirrhosis and their relation to the biomarkers of liver diseases are also discussed in the present review.
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