期刊
PROTEOMICS CLINICAL APPLICATIONS
卷 3, 期 2, 页码 148-154出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/prca.200800153
关键词
Glycan; Lectin; Oral cancer; Protein microarray
资金
- PHS [R21-CA122806, R03-DE017144]
- UCLA School of Dentistry, Faculty Seed [U01 DE015018]
Lectin microarray is a new technology that utilizes a panel of lectins immobilized on well-defined substrate for high-throughout analysis of glycans and glycoproteins. In this article, we have reviewed the fabrication and detection schemes in lectin microarray and discussed its novel applications in glycomics. We have also demonstrated a lectin array on PDMS with MALDI-TOF-MS for glycoprotein analysis. This method has been demonstrated for differential analysis of serum glycoproteins in oral cancer and healthy control subjects.
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