期刊
PROTEOMICS CLINICAL APPLICATIONS
卷 2, 期 6, 页码 788-799出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/prca.200780076
关键词
heart; oxidative stress; phosphorylation; protein isoforms; sarcomere
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL062426] Funding Source: NIH RePORTER
- NHLBI NIH HHS [P01 HL062426] Funding Source: Medline
Myofilament proteins of the cardiac sarcomere house the molecular, machinery responsible for generating tension and pressure. Release of intracellular Ca2+ triggers myofilament tension generation and shortening, but the response to Ca2+ is modulated by changes in key regulatory proteins. We review,how these proteomic changes are essential to adaptive physiological regulation of cardiac output and become maladaptive in cardiac disorders. We also review the essentials of proteomic techniques used to study myofilament protein changes, including degradation, isoform expression, phosphorylation and oxidation. Selected proteomic studies illustrate the applications of these approaches.
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