期刊
PROTEOMICS
卷 14, 期 20, 页码 2242-2248出版社
WILEY
DOI: 10.1002/pmic.201400249
关键词
Alternative splicing; Bioinformatics; Domain-domain interaction; Protein-protein interactions; RNA-seq; Tissue-specific
资金
- Senior Research Fellowship (SRF) from University Grants Commission (UGC), India
- CDFD
The functional repertoire of genes in the eukaryotic organisms is enhanced by the phenomenon of alternative splicing. Hence, a node in a tissue specific protein-protein interaction (TS PPIN) network can be thought of as an ensemble of various spliced protein products of the corresponding gene expressed in that tissue. Here we demonstrate that the nodes that occupy topologically central positions characterized by high degree, betweenness, closeness, and eigenvector centrality values in TS PPINs of Homo sapiens are associated with high number of splice variants. We also show that the high centrality of these genes/nodes could in part be explained by the presence of a large number of promiscuous domains.
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