期刊
PROTEOMICS
卷 14, 期 16, 页码 1933-1942出版社
WILEY
DOI: 10.1002/pmic.201400030
关键词
Biomarkers; Biomedicine; H1N1; Influenza virus; Plasma proteins
资金
- TEPIK (Transgovernmental Enterprise for Pandemic Influenza in Korea)
- Korea Healthcare Technology R&D Project by Ministry of Health & Welfare, Republic of Korea [A103001]
This study profiled the plasma proteins of patients infected by the 2011 H1N1 influenza virus. Differential protein expression was identified in plasma obtained from noninfected control subjects (n = 15) and H1N1-infected subjects (n = 15). Plasma proteins were separated by a 2DE large gel system and identified by nano-ultra performance LC-MS. Western blot assays were performed to validate proteins. Eight plasma proteins were upregulated and six proteins were downregulated among 3316 plasma proteins in the H1N1-infected group as compared with the control group. Of 14 up-and downregulated proteins, nine plasma proteins were validated by Western blot analysis. Putative protein FAM 157A, leucine-rich alpha 2 glycoprotein, serum amyloid A protein, and dual oxidase 1 showed significant differential expression. The identified plasma proteins could be potential candidates for biomarkers of H1N1 influenza viral infection. Further studies are needed to develop these proteins as diagnostic biomarkers.
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