期刊
PROTEOMICS
卷 13, 期 3-4, 页码 538-557出版社
WILEY
DOI: 10.1002/pmic.201200328
关键词
Bioinformatics; Cell biology; Electrophoresis; MS; Proteinprotein interactions
资金
- Clarkson University
- Keep a Breast Foundation [KEABF-375-35054]
- Redcay Foundation (SUNY Plattsburgh)
- US Army research office through the Defense University Research Instrumentation Program (DURIP) [W911NF-11-1-0304]
- US National Institutes of Health [GM103479]
- US Department of Energy [DE-FC03-02ER6342]
- private donations
This article presents an overview of the literature and a review of recent advances in the analysis of stable and transient proteinprotein interactions (PPIs) with a focus on their function within cells, organs, and organisms. The significance of PTMs within the PPIs is also discussed. We focus on methods to study PPIs and methods of detecting PPIs, with particular emphasis on electrophoresis-based and MS-based investigation of PPIs, including specific examples. The validation of PPIs is emphasized and the limitations of the current methods for studying stable and transient PPIs are discussed. Perspectives regarding PPIs, with focus on bioinformatics and transient PPIs are also provided.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据