期刊
PROTEOMICS
卷 12, 期 9, 页码 1333-1336出版社
WILEY
DOI: 10.1002/pmic.201100534
关键词
Bioinformatics; Database; Proteome annotation; Sequence analysis; Tandem repeats
资金
- Ministere de l'Education Nationale, de la Recherche et de la Technologie (MENRT)
Rapidly increasing genomic data present new challenges for scientists: making sense of millions of amino acid sequences requires a systematic approach and information about their 3D structure, function, and evolution. Over the last decade, numerous studies demonstrated the fundamental importance of protein tandem repeats and their involvement in human diseases. Bioinformatics analysis of these regions requires special computer programs and databases, since the conventional approaches predominantly developed for globular domains have limited success. To perform a global comparative analysis of protein tandem repeats, we developed the Protein Tandem Repeat DataBase (PRDB). PRDB is a curated database that includes the protein tandem repeats found in sequence databanks by the T-REKS program. The database is available at http://bioinfo.montp.cnrs.fr/?r=repeatDB
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