期刊
PROTEOMICS
卷 11, 期 15, 页码 3232-3243出版社
WILEY
DOI: 10.1002/pmic.201100087
关键词
2-DE; Aspergillus; Fungal proteomics; LC-MS/MS; Microbiology; Stress response
资金
- DFG [1160]
- German-Israeli Foundation for Scientific Research and Development (GIF)
- ESF Research Networking Programme FUMINOMICS
- International Leibniz Research School for Microbial and Biomolecular Interactions Jena (ILRS)
Fungal species of the genus Aspergillus play significant roles as model organisms in basic research, as cell factories for the production of organic acids, pharmaceuticals or industrially important enzymes and as pathogens causing superficial and invasive infections in animals and humans. The release of the genome sequences of several Aspergillus sp. has paved the way for global analyses of protein expression in Aspergilli including the characterisation of proteins, which have not designated any function. With the application of proteomic methods, particularly 2-D gel and LC-MS/MS-based methods, first insights into the composition of the proteome of Aspergilli under different growth and stress conditions could be gained. Putative targets of global regulators led to the improvement of industrially relevant Aspergillus strains and so far not described Aspergillus antigens have already been discovered. Here, I review the recent proteome data generated for the species Aspergillus nidulans, Aspergillus fumigatus, Aspergillus niger, Aspergillus terreus, Aspergillus flavus and Aspergillus oryzae.
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