期刊
PROTEOMICS
卷 11, 期 4, 页码 571-589出版社
WILEY
DOI: 10.1002/pmic.201000397
关键词
COFRADIC; Co-translational modifications; Post-translational modifications; SCX; Targeted proteomics; Technology
资金
- NGI [050-71-050]
- Netherlands Genomics Initiative
Protein modifications are biologically important events that may be studied by mass spectrometry-based high-throughput proteome analyses. In recent years, several new technologies have emerged that have widened and deepened the targeted analysis of one important, albeit functionally ill-defined modification, namely protein acetylation. This modification can take place both co- and post-translationally by the transfer of acetyl groups under the catalysis of acetyltransferases. The acetyl group can modify either the alpha-amino group at the N-terminus, so-called N-terminal acetylation, or the epsilon-amino group on the side chain of lysine residues. Here, we review several emerging targeted technologies to chart both N-terminal acetylation as well as acetylation at the lysine side chain, on a proteome-wide scale, highlighting in particular studies that have expanded the biological knowledge on the appearance and function of these common but functionally still less investigated co- and post-translational modifications.
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