期刊
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
卷 82, 期 9, 页码 1850-1868出版社
WILEY
DOI: 10.1002/prot.24538
关键词
coopetition; protein structure prediction; CASP; structure refinement; Foldit
资金
- Office of Science of the U.S. Department of Energy [DE-AC02-05CH11231]
- National Institutes of Health [R01GM052032, R01GM093123, GM063817]
- National Science Foundation
- National Science Foundation Graduate Research Fellowship [DGE-1148900]
- Brazilian funding agency Coordination of the Enhancement of Higher Education (CAPES)
- Brazilian funding agency Sao Paulo Research Foundation (FAPESP)
- US National Institutes of Health [GM-14312]
- US National Science Foundation [MCB10-19767]
- Polish National Science Center [UMO-2012/06/A/ST4/00376, UMO-2011/01/N/ST4/01772]
- Foundation for Polish Science [MPD/2010/5]
- Division of General Medical Sciences of the National Institutes of Health [GM-48835, GM-37408, GM-08422]
- Office of Naval Research [N00014-12-C-0158]
- BSF [2009432]
The protein structure prediction problem continues to elude scientists. Despite the introduction of many method modest gains were made over the last decade for certain classes of prediction targets. To address this challenge, a social. media based worldwide collaborative effort, named WeFold, was undertaken by 13 labs. During the collaboration, the laboratories were simultaneously competing with each other. Here, we present the first attempt at coopetition in scientific research applied to the protein structure prediction and refinement problems. The coopetition was possible by allowing e participating labs to contribute different components of their protein structure prediction pipelines and create new hybrid pipelines that they tested during CASP10. This manuscript describes both successes and areas needing improvement as identified throughout the first WeFold experiment and discusses the efforts that are underway to advance this initiative. A footprint of all contributions and structures are publicly accessible at http://www.wefold.org.
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