相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Exploring the sequence determinants of amyloid structure using position-specific scoring matrices
Sebastian Maurer-Stroh et al.
NATURE METHODS (2010)
Identifying the amylome, proteins capable of forming amyloid-like fibrils
Lukasz Goldschmidt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
H-1, C-13 and N-15 assignments of a camelid nanobody directed against human alpha-synuclein
Anneleen Vuchelen et al.
BIOMOLECULAR NMR ASSIGNMENTS (2009)
Formulation and manufacturability of biologics
Steven J. Shire
CURRENT OPINION IN BIOTECHNOLOGY (2009)
General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold
Cecile Vincke et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Aggregation-resistant VHs selected by in vitro evolution tend to have disulfide-bonded loops and acidic isoelectric points
M. Arbabi-Ghahroudi et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2009)
Sequence determinants of protein aggregation in human VH domains
Kip Dudgeon et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2009)
The influence of the framework core residues on the biophysical properties of immunoglobulin heavy chain variable domains
Annemarie Honegger et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2009)
Conserved amino acid networks involved in antibody variable domain interactions
Norman Wang et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2009)
Thermodynamically stable aggregation-resistant antibody domains through directed evolution
Kristoffer Famm et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Effects of solution conditions, processing parameters, and container materials on aggregation of a monoclonal antibody during freeze-thawing
Lisa A. Kueltzo et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2008)
Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains
Pierre A. Barthelemy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aβ protofibrils
Gernot Habicht et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Exploring the capacity of minimalist protein interfaces:: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope
Akiko Koide et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
The PASTA server for protein aggregation prediction
Antonio Trovato et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2007)
Supercharging proteins can impart unusual resilience
Michael S. Lawrence et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
AGGRESCAN:: a server for the prediction and evaluation of hot spots of aggregation in polypeptides
Oscar Conchillo-Sole et al.
BMC BIOINFORMATICS (2007)
Improving solubility and refolding efficiency of human VHs by a novel mutational approach
Jamshid Tanha et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2006)
The 3D profile method for identifying fibril-forming segments of proteins
MJ Thompson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Antigen binding and solubility effects upon veneering of a camel VHH in framework-2 to the mimic a VH
K Conrath et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Protein production by auto-induction in high-density shaking cultures
FW Studier
PROTEIN EXPRESSION AND PURIFICATION (2005)
Applications of ribosome display to antibody drug discovery
MAT Groves et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2005)
Crystal structure of HEL4, a soluble, refoldable Human VH single domain with a germ-line scaffold
L Jespers et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
A comparative study of the relationship between protein structure and β-aggregation in globular and intrinsically disordered proteins
R Linding et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Aggregation-resistant domain antibodies selected on phage by heat denaturation
L Jespers et al.
NATURE BIOTECHNOLOGY (2004)
A new approach for rapidly reshaping single-chain antibody in vitro by combining DNA shuffling with ribosome display
XB Wang et al.
JOURNAL OF BIOCHEMISTRY (2004)
Anchored periplasmic expression, a versatile technology for the isolation of high-affinity antibodies from Escherichia coli-expressed libraries
BR Harvey et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Contributions of CDR3 to VHH domain stability and the design of monobody scaffolds for naive antibody libraries
CJ Bond et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Biophysical properties of human antibody variable domains
S Ewert et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Domain antibodies: proteins for therapy
LJ Holt et al.
TRENDS IN BIOTECHNOLOGY (2003)
Single-domain antibody fragments with high conformational stability
M Dumoulin et al.
PROTEIN SCIENCE (2002)
Solution structure of a llama single-domain antibody with hydrophobic residues typical of the VH/VL interface
W Vranken et al.
BIOCHEMISTRY (2002)
DNAWorks: an automated method for designing oligonucleotides for PCR-based gene synthesis
DM Hoover et al.
NUCLEIC ACIDS RESEARCH (2002)
Selection by phage display of llama conventional VH fragments with heavy chain antibody VHH properties
J Tanha et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2002)
Biophysical properties of camelid VHH domains compared to those of human VH3 domains
S Ewert et al.
BIOCHEMISTRY (2002)
Recognition of antigens by single domain antibody fragments: the superfluous luxury of paired domains
S Muyldermans et al.
TRENDS IN BIOCHEMICAL SCIENCES (2001)
Thermal unfolding of a llama antibody fragment:: A two-state reversible process
JMJ Pérez et al.
BIOCHEMISTRY (2001)
Phage display in pharmaceutical biotechnology
SS Sidhu
CURRENT OPINION IN BIOTECHNOLOGY (2000)
Llama heavy-chain V regions consist of at least four distinct subfamilies revealing novel sequence features
MM Harmsen et al.
MOLECULAR IMMUNOLOGY (2000)
Induction of immune responses and molecular cloning of the heavy chain antibody repertoire of Lama glama
R van der Linden et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2000)
Camel heavy-chain antibodies: diverse germline VHH and specific mechanisms enlarge the antigen-binding repertoire
VK Nguyen et al.
EMBO JOURNAL (2000)
分享论文
