期刊
PROTEIN SCIENCE
卷 22, 期 12, 页码 1808-1811出版社
WILEY
DOI: 10.1002/pro.2383
关键词
scoring function; binding free energy; protein-RNA docking; binding affinity benchmark
资金
- National Natural Science Foundation of China [31100522]
- National High Technology Research and Development Program of China [2012AA020402]
- Specialized Research Fund for the Doctoral Program of Higher Education [20110142120038]
We have developed a non-redundant protein-RNA binding benchmark dataset derived from the available protein-RNA structures in the Protein Database Bank. It consists of 73 complexes with measured binding affinity. The experimental conditions (pH and temperature) for binding affinity measurements are also listed in our dataset. This binding affinity dataset can be used to compare and develop protein-RNA scoring functions. The predicted binding free energy of the 73 complexes from three available scoring functions for protein-RNA docking has a low correlation with the binding Gibbs free energy calculated from K-d. (c) 2013 The Protein Society
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