4.6 Article

The dataset for protein-RNA binding affinity

期刊

PROTEIN SCIENCE
卷 22, 期 12, 页码 1808-1811

出版社

WILEY
DOI: 10.1002/pro.2383

关键词

scoring function; binding free energy; protein-RNA docking; binding affinity benchmark

资金

  1. National Natural Science Foundation of China [31100522]
  2. National High Technology Research and Development Program of China [2012AA020402]
  3. Specialized Research Fund for the Doctoral Program of Higher Education [20110142120038]

向作者/读者索取更多资源

We have developed a non-redundant protein-RNA binding benchmark dataset derived from the available protein-RNA structures in the Protein Database Bank. It consists of 73 complexes with measured binding affinity. The experimental conditions (pH and temperature) for binding affinity measurements are also listed in our dataset. This binding affinity dataset can be used to compare and develop protein-RNA scoring functions. The predicted binding free energy of the 73 complexes from three available scoring functions for protein-RNA docking has a low correlation with the binding Gibbs free energy calculated from K-d. (c) 2013 The Protein Society

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