期刊
PROTEIN SCIENCE
卷 18, 期 12, 页码 2624-2628出版社
WILEY
DOI: 10.1002/pro.256
关键词
topology; structure prediction; transmembrane helices; hydropathy plots; hydrophobicity; membrane protein explorer
资金
- National Institute of General Medical Sciences [GM046823, GM068002, GM074637, GM086685]
- National Institute of Neurological Disorders and Stroke [GM086685]
Hydropathy plot methods form a cornerstone of membrane protein research, especially in the early stages of biochemical and structural characterization. Membrane Protein Explorer (MPEx), described in this article, is a refined and versatile hydropathy-plot software tool for analyzing membrane protein sequences. MPEx is highly interactive and facilitates the characterization and identification of favorable protein transmembrane regions using experiment-based physical and biological hydrophobicity scales. Besides allowing the consequences of sequence mutations to be examined, it provides tools for aiding the design of membrane-active peptides. MPEx is freely available as a Java Web Start application from our web site at http://blanco.biomol.uci.edu/mpex.
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