期刊
PROTEIN SCIENCE
卷 10, 期 7, 页码 1293-1304出版社
COLD SPRING HARBOR LAB PRESS
DOI: 10.1110/ps.51201
关键词
protein cross-linking; cross-linking reagents; molecular rulers; stochastic dynamics
资金
- NIAMS NIH HHS [R01 AR022031, AR 22031] Funding Source: Medline
- NIGMS NIH HHS [GM 61402, R01 GM061402] Funding Source: Medline
Homobifunctional chemical cross-linking reagents are important tools for functional and structural characterization of proteins. Accurate measures of the lengths of these molecules currently are not available, despite their widespread use. Stochastic dynamics calculations now provide quantitative measures of the lengths, and length dispersions, of 32 widely used molecular rulers. Significant differences from published data have been found.
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