期刊
PROTEIN SCIENCE
卷 17, 期 8, 页码 1295-1307出版社
WILEY
DOI: 10.1110/ps.03259908
关键词
conformational change; MWC; Pauling-KNF; allostery; protein dynamics
资金
- NIGMS NIH HHS [R01-GM30804, G01-GM071428, R01 GM071428, R01 GM030804] Funding Source: Medline
Although phenomenlogical models that account for cooperativity in allosteric systems date back to the early and mid- 60' s ( e. g., the KNF and MWC models), there is resurgent interest in the topic due to the recent experimental and computational studies that attempted to reveal, at an atomistic level, how allostery actually works. In this review, using systems for which atomistic simulations have been carried out in our groups as examples, we describe the current understanding of allostery, how the mechanisms go beyond the classical MWC/ Pauling- KNF descriptions, and point out that the `` new view'' of allostery, emphasizing `` population shifts,'' is, in fact, an `` old view.'' The presentation offers not only an up- to- date description of allostery from a theoretical/ computational perspective, but also helps to resolve several outstanding issues concerning allostery.
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