期刊
PROTEIN ENGINEERING DESIGN & SELECTION
卷 25, 期 11, 页码 797-802出版社
OXFORD UNIV PRESS
DOI: 10.1093/protein/gzs075
关键词
crystal structure; LPS synthesis; O-antigens; polysaccharides
资金
- Canadian Institutes of Health Research (CIHR) [MOP-89787]
The O-antigen lipopolysaccharides on bacterial surface contain variable number of oligosaccharide repeat units with their length having a modal distribution specific to the bacterial strain. The polysaccharide length distribution is controlled by the proteins called polysaccharide co-polymerases (PCPs), which are embedded in the inner membrane in Gram-negative bacteria and form homo oligomers. The 3D structures of periplasmic domains of several PCPs have been determined and provided the first insights into the possible mechanism of polysaccharide length determination mechanism. Here we review the current knowledge of structure and function of these polysaccharide length regulators.
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