期刊
PROTEIN AND PEPTIDE LETTERS
卷 19, 期 11, 页码 1231-1236出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986612803217114
关键词
Solid-phase synthesis; Fmoc-amino acid; synthesis in water; difficult sequence; nanoparticles; microwave-assisted synthesis
资金
- Strategic Research Foundation at Private Universities matching fund subsidy from the Japanese Ministry of Education, Culture, Sports, Science and Technology
A microwave assisted peptide synthesis in water using nanosized Fmoc-amino acids was developed. 5, 7, and 10 mer peptides (Leu-enkephalinamide, dermorphinamide, and a typical difficult sequence, ACP (65-74) peptide) were successfully synthesized in water according to Fmoc chemistry using water-dispersible nanoparticles with microwave irradiation.
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