Peptoid Analogues of Anoplin Show Antibacterial Activity

We have synthesised nine analogues of the antibacterial peptide anoplin with a peptoid residue at position 5 (H-GLLKXIKTLL-NH2). The most active compounds showed MIC-values of 12.5 and 25 mu M against E. coli and S. aureus. These MIC-values are comparable with anoplin which showed 23 mu M and 11 M against E. coli and S. aureus. However, the selectivity was reversed. Our results indicate that peptoid analogues of anoplin are promising lead structures for developing new antibacterial agents.