期刊
PROTEIN AND PEPTIDE LETTERS
卷 16, 期 9, 页码 1006-1011出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986609789055421
关键词
Anoplin; antibacterial agents; peptoid; solid-phase synthesis
We have synthesised nine analogues of the antibacterial peptide anoplin with a peptoid residue at position 5 (H-GLLKXIKTLL-NH2). The most active compounds showed MIC-values of 12.5 and 25 mu M against E. coli and S. aureus. These MIC-values are comparable with anoplin which showed 23 mu M and 11 M against E. coli and S. aureus. However, the selectivity was reversed. Our results indicate that peptoid analogues of anoplin are promising lead structures for developing new antibacterial agents.
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