期刊
PROTEIN AND PEPTIDE LETTERS
卷 16, 期 6, 页码 664-667出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986609788490267
关键词
Bone; fibroblast growth factor 2; fusion; hydroxyapatite; osteocalcin
资金
- Ministry of Knowledge Economy, Republic of Korea
- Korea Health 21 RD Project
- Ministry of Health & Welfare, Republic of Korea [A05-0300-AA1018-06A200010A]
The engineering of a novel FGF2 fused with highly conserved bone mineral-binding domain of osteocalcin (OC) for targeting to bone mineral hydroxyapatite (HA) exhibited much stronger HA-binding affinity than native FGF2. FGF2-OC also showed a significant increase of mitogenic activity and cellular differentiation of osteoblastic cells compared with native FGF2.
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