期刊
PROTEIN AND PEPTIDE LETTERS
卷 15, 期 5, 页码 536-540出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986608784567618
关键词
antimicrobial peptide; innate immunity; host defense; signal sequence
资金
- US Public Health Service [R01 DE14897, R01 HL67871]
- Cystic Fibrosis Foundation
Antimicrobial peptides (AMPs) are generally produced as precursor peptides containing a signal sequence, a pro-region and the mature peptide. A computational analysis of beta-defensin precursors predicts cleavage solely by signal peptidase to release the mature peptide, with no pro-region. This supports the extensive transcriptional control of beta-defensin expression compared with other AMP genes.
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