期刊
ACS COMBINATORIAL SCIENCE
卷 18, 期 1, 页码 1-14出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscombsci.5b00087
关键词
Click Chemistry; CuAAC; solid-phase; azide; alkyne
资金
- CICYT [CTQ2012-30930]
- Generalitat de Catalunya [2014 SGR 137]
- Institute for Research in Biomedicine Barcelona (IRB Barcelona)
Click chemistry is an approach that uses efficient and reliable reactions, such as Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC), to bind two molecular building blocks. CuAAC has broad applications in medicinal chemistry and other fields of chemistry. This review describes the general features and applications Of CuAAC in solid-phase synthesis (CuAAC-SP), highlighting the suitability of this kind of reaction for peptides, nucleotides, small molecules, supramolecular structures, and polymers, among others. This versatile reaction is expected to become pivotal for meeting future challenges in solid-phase chemistty.
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