期刊
ACS COMBINATORIAL SCIENCE
卷 17, 期 6, 页码 374-380出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscombsci.5b00046
关键词
2,3,64-trisubstituted pyridines; 5,6,7,8-tetrahydroquinolines; Mannich bases; pyridine synthesis in water
资金
- Scientific and Technological Research Council of TURKEY [113Z044]
- TUBITAK
A highly efficient, regioselective, and environmentally friendly method has been developed for water-mediated synthesis of 2,3,6-trisubstituted pyridines and 5,6,7,8-tetrahydroquinolines. The introduced method allows easy preparation of various polysubstituted pyridines and 5,6,7,8-tetrahydroquinolines via domino reaction of an enolizable ketone, ammonia and enones derived from different Mannich bases in mild reaction conditions. Montmorillonite K-10 promoted this one-pot three-component reaction and gave both new and known 2,3,6-trisubstituted pyridines and 5,6,7,8-tetrahydroquinolines in good yields. The reaction protocol provides a wide array of functionality in construction of polysubstituted pyridines and 5,6,7,8-tetrahydroquinolines from commercially available starting materials in easily applicable and environmentally friendly conditions.
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