期刊
PROSTATE CANCER AND PROSTATIC DISEASES
卷 13, 期 4, 页码 311-315出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/pcan.2010.31
关键词
C-MYC oncogene; quantitative expression; recurrence
资金
- National Institutes of Health [5R01 DK065977]
Alterations of chromosome 8, including amplification at 8q24 harboring the C-MYC oncogene, have been noted as one of the most common chromosomal abnormalities in prostate cancer (CaP) progression. However, the frequency of C-MYC alterations in CaP has remained uncertain. A recent study, using a new anti-MYC antibody, described prevalent upregulation of nuclear C-MYC protein expression as an early oncogenic alteration in CaP. Further, we have recently reported regulation of C-MYC expression by ERG and a significant correlation between C-MYC overexpression and TMPRSS2-ERG fusion in early stage CaP. These emerging data suggest that increased C-MYC expression may be a critical and early oncogenic event driving CaP progression. In this study, we assessed whether C-MYC mRNA overexpression in primary prostate tumors was predictive of more aggressive tumor or disease progression. Our approach was to quantitatively determine C-MYC mRNA expression levels in laser capture micro-dissected tumor cells and matched benign epithelial cells in a radical prostatectomy cohort with long follow-up data available. On the basis of our results, we conclude that elevated C-MYC expression in primary prostate tumor is biologically relevant and may be a predictor of future biochemical recurrence. Prostate Cancer and Prostatic Diseases (2010) 13, 311-315; doi: 10.1038/pcan.2010.31; published online 7 September 2010
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