期刊
PROSTATE
卷 72, 期 10, 页码 1052-1059出版社
WILEY-BLACKWELL
DOI: 10.1002/pros.22496
关键词
prostate cancer; retinoid X receptor a; PIN; New Western Diet; prostate-specific gene knockout
资金
- UCLA Clinical Nutrition Research Unit [P30 CA 42710]
- NIH [CA T32 CA09142, RO1 CA59705]
- NCI [5-R25-CA87949, K07 CA98880]
- NCE Division of Cancer Prevention
- UCLA Center for Nutritional Research
- UCLA Division of Cancer Prevention and Control Research
- UCLA School of Public Health
- Jonsson Comprehensive Cancer Center
BACKGROUND The New Western-style Diet (NWD) characterized by high in fat and low in fiber, vitamin D, calcium, and methyl donorsare considered as a risk factor for prostate cancer. Previous studies have shown that premalignant lesions of human prostate have decreased expression of the Retinoid X Receptor alpha (RXRa). This study was to determine the effect of diet in RXRa knockout mice in developing high-grade prostate intraepithelial neoplasia (mPIN). METHODS Male mice (n?=?54) with or without the RXRa prostate null mutation were fed either NWD or AIN-76A control diet for 10 months; prostates were harvested at 11 months of age and examined for prostate mPIN. RESULTS mPIN was seen in 79% of RXRa prostate null mice fed NWD (n?=?19), 30.8% RXRa prostate null mice fed AIN-76A (n?=?13), 42.9% RXRa wild-type mice fed NWD (n?=?14), and 12.5% RXRa wild-type mice fed AIN-76A (n?=?8). Unconditional Logistic analysis showed a significant joint effect of NWD and RXRa status in developing mPIN 26.3 (95% CI: 2.5280), but interaction was not significant owing to the small sample size 1.6 (0.0927.7, P?=?0.7441). CONCLUSION This study provides preliminary data to support a joint RXRa-diet effect in prostate carcinogenesis. Prostate 72:10521059, 2012. (c) 2012 Wiley Periodicals, Inc.
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