期刊
PROSTATE
卷 72, 期 15, 页码 1678-1687出版社
WILEY
DOI: 10.1002/pros.22521
关键词
prostate cancer; NRBP1; Madm; TSC-22; Ki67; proliferation; Gleason; survival; castration resistance
资金
- Krebsliga beider Basel [07-2010]
BACKGROUND We recently established the rationale that NRBP1 (nuclear receptor binding protein 1) has a potential growth-promoting role in cell biology. NRBP1 interacts directly with TSC-22, a potential tumor suppressor gene that is differently expressed in prostate cancer. Consequently, we analyzed the role of NRBP1 expression in prostate cancer cell lines and its expression on prostate cancer tissue microarrays (TMA). METHODS The effect of NRBP1 expression on tumor cell growth was analyzed by using RNAi. NRBP1 protein expression was evaluated on two TMAs containing prostate samples from more than 1,000 patients. Associations with clinico-pathological features, the proliferation marker Ki67 and survival data were analyzed. RESULTS RNAi mediated silencing of NRBP1 expression in prostate cancer cell lines resulted in reduced cell growth (P?
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