A Functional Polymorphism in MSMB Gene Promoter Is Associated With Prostate Cancer Risk and Serum MSMB Expression

BACKGROUND. To explore the reported association of SNP marker rs10993994 with prostate cancer identified by two independent in two genome-wide association studies (GWAS) further, we performed a case-control study in southern Chinese Han population. Consequently, we detected the serum levels of MSMB expression with different genotypes in the cases and controls to characterize the functional consequences of rs10993994. MATERIALS AND METHODS. Two hundred fifty-one prostate cancer and 258 control subjects were included in the cancer association study and 90 serum samples were used to test the expression of the MSMB by Enzyme-linked immunosorbent assay (ELISA). RESULTS. We found that the T allele displayed an increased prevalence of prostate cancer compared with the C allele (OR = 1.30, 95% CI = 1.01-1.67, P = 0.040). Moreover, the prostate cancer patients carrying CT/TT genotype had significantly decreased serum MSMB levels compared to those with CC genotype (16.32 +/- 3.98 mu g/L vs. 19.33 +/- 4.27 mu g/L, P = 0.022). CONCLUSIONS. rs10993994 in MSMB promoter affects serum MSMB expression, contributes to the genetic predisposition to prostate cancer in southern Chinese Han population. Prostate 70: 1146-1152, 2010. (C) 2010 Wiley-Liss, Inc.