期刊
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
卷 90, 期 6, 页码 199-206出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2014.03.001
关键词
n-3 PUFA; Muscle; FAK
资金
- Sporting Chance Initiative
- MRC [MR/K00414X/1] Funding Source: UKRI
- Medical Research Council [MR/K00414X/1] Funding Source: researchfish
The aim of this study was to examine changes in the lipid profile of red blood cells and muscle tissue along with the expression of anabolic signalling proteins in human skeletal muscle. Following a 2-week control period, 10 healthy male participants consumed 5 g d(-1) of fish oil (FO) for 4 weeks. Muscle biopsies and venous blood samples were collected in the fasted state 2 weeks prior (W-2) and immediately before (WO) the initiation of FO supplementation for internal control. Muscle biopsies and venous blood samples were again obtained at week I (W1), 2 (W2) and 4 (W4) during FO supplementation for assessment of changes in lipid composition and expression of anabolic signalling proteins. There was no change in the composition of any lipid class between W-2 and WO confirming control. Following FO supplementation n-3 polyunsaturated fatty acid (n-3 PUFA) muscle lipid composition was increased from WO to W2 and continued to rise at W4. n-3 PUFA blood lipid composition was increased from WO to W1 and remained elevated for the remaining time points. Total protein content of focal adhesion kinase (FAK) increased from WO to W4 whereas total mechanistic target of rapamycin (mTOR) was increased from WO at W1 with no further significant increases at W2 and W4. These data show that FO supplementation results in discordant changes in the n-3 PUFA composition of skeletal muscle compared to blood that is associated with increases in total FAX content. (C) 2014 Elsevier Ltd. All rights reserved.
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