期刊
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
卷 89, 期 5, 页码 297-303出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2013.09.007
关键词
Cysteine; Sulfur amino acids; Stearoyl-CoA desaturase; Fatty acid profile
资金
- Advanced Research Programme of Norway
- Research Council of Norway
- Norwegian Rheumatism Association
- Johan Throne Hoist Foundation for Nutrition Research
- Norman Collisson Foundation
- University of Oslo, Norway
In rats, dietary restriction of the cysteine precursor methionine suppresses hepatic stearoyl-CoA desaturase (SCD)-1 expression and activity, whereas cysteine supplementation reverses these effects. In 2 independent cohorts: Hordaland Health Study (HUSK; N=2021, aged 71-74 y), Norway, and Hoorn study (N=686, aged 50-87 y), Netherlands, we examined the cross-sectional associations of plasma sulfur-containing compounds (SCC; methionine, S-adenosylmethionine, S-adenosylhomocysteine, homocysteine, cystathionine, total cysteine (tCys), glutathione and cysteinylglycine) with SCD-16 index (16:1n-7/16:0), estimated from fatty acid profiles of total plasma or serum lipids. Only tCys was consistently associated with SCD-16 index after adjustments for sex and age (HUSK: partial r=0.14; Hoorn: partial r=0.11, P<0.001 for both), and after further adjustments for other SCC, body fat, diet, exercise and plasma lipids (HUSK: partial r=0.07, P=0.004; Hoorn: partial r=0.12, P=0.013). Together with animal data showing an effect of dietary cysteine on SCD1, our results suggest a role for cysteine in SCD1 regulation in humans. (C) 2013 Elsevier Ltd. All rights reserved.
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