期刊
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
卷 85, 期 2, 页码 75-81出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2011.04.024
关键词
Mycobacterium tuberculosis; Prostaglandins; Leukotrienes; Cytokines; Immunomodulation
资金
- FAPESP [01/12400-6, 02/12856-2, 00/09663-2]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao de Amparo ao Ensino, Pesquisa e Assistencia do Hospital das Clinicas da FMRP-USP (FAEPA)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [02/12856-2] Funding Source: FAPESP
Prostaglandins (PGs) and leukotrienes (LTs) are produced in Mycobacterium tuberculosis (Mtb)-infected lungs and have immune suppressive and protective effects, respectively. Considering that both of these mediators are produced during mycobacterial infection, we investigated the specific and relative biological importance of each in regulating host response in experimental tuberculosis. Administration of celecoxib, which was found to reduce lung levels of PGE(2) and increase LTB4, enhanced the 60-day survival of Mtb-infected mice in 14%. However administration of MK-886, which reduced levels of LTB4 but did not enhance PGE(2), reduced 60-day survival from 86% to 43% in Mtb-infected mice, and increased lung bacterial burden. MK-886 plus celecoxib reduced survival to a lesser extent than MK-886 alone. MK-886- and MK-886 plus celecoxib-treated animals exhibited reduced levels of the protective interleukin-12 and gamma-interferon. Our findings indicate that in this model, the protective effect of LTs dominates over the suppressive effect of PGs. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据