期刊
PROSTAGLANDINS & OTHER LIPID MEDIATORS
卷 139, 期 -, 页码 1-9出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2018.09.002
关键词
Omega-3 PUFA; Eicosanoid; Myocardial infarction; Metabolomics
资金
- National Natural Science Foundation of China [91539108, 81870188, 81420108003, 91439206, 31230035]
- Tianjin Municipal Science and Technology Project [14JCYBJC41800]
- Ministry of Science and technology of China [2016YFC0903000]
Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation is a recommended preventive approach against cardiovascular diseases, but its mechanism of protection against myocardial infarction (MI) injury is not fully understood. Eicosanoid metabolomics demonstrated an abnormal eicosanoid profile was in the plasma of mice receiving MI surgery. 19,20-EDP, 17,18-EEQ, 14,15-EET and 9,10-EpOME were decreased, and PGE(2) was increased by the surgery. N-3 PUFA-rich diets feeding or transgene of Fat-1 shifted the eicosanoid profile to an n-3 PUFA dominant style and attenuated the myocardial infarction injury. Multiple logistic regression analysis suggested the degree of MI injury was related with an eicosanoid pattern, composed by eicosanoids derived from both n-3 and n-6 PUFA in the three enzymatic pathways. These results suggested the benefits of n-3 PUFA on MI was achieved synergistically.
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