期刊
PROSTAGLANDINS & OTHER LIPID MEDIATORS
卷 104, 期 -, 页码 122-129出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2012.07.003
关键词
S1P; SDF-1; CXCR4; Stem cell mobilization; MAC
资金
- Grant Maestro [2011/02/A/NZ4/00035]
- NIH [2R01 DK070577]
- Stella and Henry Endowment
Under steady-state conditions, hematopoietic stem/progenitor cells (HSPCs) egress from bone marrow (BM) and enter peripheral blood (PB) where they circulate at low levels. Their number in PB, however, increases significantly in several stress situations related to infection, organ/tissue damage, or strenuous exercise. Pharmacologically mediated enforced egress of HSPCs from the BM microenvironment into PB is called mobilization, and this phenomenon has been exploited in hematological transplantology as a means to obtain HSPCs for hematopoietic reconstitution. In this review we will present the accumulated evidence that innate immunity, including the complement cascade and the granulocyte/monocyte lineage, and the PB plasma level of the bioactive lipid sphingosine-1-phosphate (S1P) together orchestrate this evolutionarily conserved mechanism that directs trafficking of HSPCs. (C) 2012 Elsevier Inc. All rights reserved.
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