期刊
PROSTAGLANDINS & OTHER LIPID MEDIATORS
卷 98, 期 3-4, 页码 91-93出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2011.11.008
关键词
Epoxyeicosatrienoic acids; Red blood cells
资金
- National Institutes of Health [HL34300]
Red blood cells (RBCs) have an important function in regulation of the circulation by producing and releasing epoxyeicosatrienoic acids (EETs) in response to a low O-2 environment such as encountered in the cardiac microcirculation during exercise. RBCs, in their role as sensors of low pO(2), release ATP and critical lipid mediators, the EETs. Both cis- and trans-EETs are synthesized and stored in RBCs and are hydrolyzed by soluble epoxide hydrolases (sEH). The trans-EETs differ from cis-EETs in their higher vascular potencies and more rapid metabolism by sEH. Thus, inhibition of sEH results in greater trans-EET levels and increased positive vascular effects of trans-EETs vs cis-EETs. The trans-EETs are responsible for a significant decline in the elevated blood pressure in the spontaneously hypertensive rat on treatment with a sEH inhibitor to raise EET levels. We predict that trans-EETs and cis-EETs will occupy important therapeutic roles in a broad spectrum of diseases and abnormal physiological conditions such as that resulting from high salt intake and hypertension. (C) 2011 Elsevier Inc. All rights reserved.
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