期刊
PROSTAGLANDINS & OTHER LIPID MEDIATORS
卷 96, 期 1-4, 页码 14-20出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2011.08.005
关键词
Breast cancer; COX-2; Macrophage polarization; Microenvironment; PGE2; Regulatory T lymphocytes; Myeloid-derived suppressor cells; Immune suppression
资金
- American Cancer Society [RSG-08-024-21]
COX-derived prostanoids play multiple roles in inflammation and cancer. This review highlights research examining COX-2 and PGE(2)-dependent regulation of immune cell polarization and function within the tumor microenvironment, particularly as it pertains to breast cancer. Appreciating PGE(2)-mediated immunomodulation is important in understanding how tumors evade immune surveillance by re-educating infiltrating inflammatory and immune cells to support tumorigenesis. Elucidation of the multiple and complex influences exerted by tumor stromal components may lead to targeted therapies in breast and other cancers that restrain microenvironmental permissiveness and maintain natural defenses against malignancies. (C) 2011 Elsevier Inc. All rights reserved.
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