期刊
PROSTAGLANDINS & OTHER LIPID MEDIATORS
卷 89, 期 3-4, 页码 73-81出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2009.04.007
关键词
G2A receptor; Lysophosphatidylcholine; Immunity; Inflammation; Chronic inflammatory disease; Autoimmunity
资金
- National Heart, Lung and Blood Institute (NHLBI) [RO1 HL088642]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) [P30 AR048311]
The G2A receptor was originally identified by virtue of its transcriptional induction in routine B lymphoid cells in response to oncogenic transformation and treatment with Various DNA-damaging agents. While preliminary characterization of cellular responses to G2A overexpression in fibroblastic cell lines suggested that this receptor may negatively regulate cell growth under conditions Of proliferative and genotoxic stress, subsequent studies driven by the discovery of lysophosphatidylcholine (LPC) as a regulator of G2A signaling in immunoregulatory cells point to an important role for this receptor in innate and adaptive immunity. (C) 2009 Elsevier Inc. All rights reserved.
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