期刊
ACS Catalysis
卷 5, 期 11, 页码 6524-6528出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.5b01793
关键词
asymmetric catalysis; nickel; styrene; quaternary stereocenter; sultam
资金
- National Natural Science Foundation of P. R. China [21372202]
- New Century Excellent Talents in University [NCET-12-1086]
- Zhejiang Natural Science Fund for Distinguished Young Scholars [LR14B020001]
Enantioselective addition of styrenes to cyclic N-sulfonyl alpha-ketiminoesters was developed using the complex of Ni(ClO4)(2) with chiral phosphine complex as a catalyst. A range of chiral benzofused 5-membered sultams bearing alkenylated or allylated alpha-tetrasubstituted amino ester framework were afforded in excellent enantioselectivities (up to 99% ee) as potential biologically active compounds for drug research.
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