期刊
ACS CATALYSIS
卷 5, 期 9, 页码 5540-5544出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.5b01417
关键词
'frustrated Lewis pairs; catalytic hydrogenation; water tolerance; solvent effects; metal-free
资金
- GreenCatEng
- Eli Lilly
- EPSRC
- Royal Society
- European Research Council [307061, 640988]
- European Research Council (ERC) [640988, 307061] Funding Source: European Research Council (ERC)
- EPSRC [EP/K039946/1, EP/K030760/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K030760/1, EP/K039946/1, 1376417] Funding Source: researchfish
Despite rapid advances in the field of metal-free, frustrated Lewis pair (FLP)-catalyzed hydrogenation, the need for strictly anhydrous reaction conditions has hampered wide-scale uptake of this methodology. Herein, we report that, despite the generally perceived moisture sensitivity of FLPs, 1,4-dioxane solutions of B(C6F5)(3) actually show appreciable moisture tolerance and can catalyze hydrogenation of a range of weakly basic substrates without the need for rigorously inert conditions. In particular, reactions can be performed directly in commercially available nonanhydrous solvents without subsequent drying or use of internal desiccants.
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