期刊
PROGRESS IN RETINAL AND EYE RESEARCH
卷 30, 期 5, 页码 343-358出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.preteyeres.2011.05.002
关键词
Diabetic retinopathy; Inflammation; Diabetes; Pathogenesis
资金
- Veteran Affairs Career Development and Foundation
- Veterans Affairs Merit Award
- PHS [EY00300]
Diabetes causes a number of metabolic and physiologic abnormalities in the retina, but which of these abnormalities contribute to recognized features of diabetic retinopathy (DR) is less clear. Many of the molecular and physiologic abnormalities that have been found to develop in the retina in diabetes are consistent with inflammation. Moreover, a number of anti-inflammatory therapies have been found to significantly inhibit development of different aspects of DR in animal models. Herein, we review the inflammatory mediators and their relationship to early and late DR, and discuss the potential of anti-inflammatory approaches to inhibit development of different stages of the retinopathy. We focus primarily on information derived from in vivo studies, supplementing with information from in vitro studies were important. (C) 2011 Elsevier Ltd. All rights reserved.
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