期刊
ACS CATALYSIS
卷 6, 期 2, 页码 526-531出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.5b02400
关键词
iron or copper catalysis; alkylidenecyclopropanes; tetracyclic benzazepine derivatives; radical addition; activated alkenes; ring opening
资金
- National Basic Research Program of China [(973)-2015CB856603]
- National Natural Science Foundation of China [20472096, 21372241, 21361140350, 20672127, 21421091, 21372250, 21121062, 21302203, 20732008, 21572052]
A novel iron- or copper-catalyzed trifluoromethylation of acrylamide-tethered alkylidenecyclopropanes with Togni reagent II to construct CF3-containing tetracyclic benzazepine derivatives under mild and convenient conditions has been disclosed. The chemoselective addition of in situ generated trifluoromethyl radical onto the activated alkenes triggers the reaction followed by a ring-opening process of alkylidenecyclopropanes, leading to the formation of two types of CF3-containing tetracyclic benzazepine derivatives in moderate to good yields, respectively, with excellent functional group tolerance.
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