期刊
PROGRESS IN RETINAL AND EYE RESEARCH
卷 27, 期 4, 页码 331-371出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.preteyeres.2008.05.001
关键词
retina; angiogenesis; vascular endothelial growth factor; age-related macular degeneration; diabetic retinopathy; retinopathy of prematurity
资金
- RPB
- VA Merit Review Award [EY04618, EY011766]
- [EY007533]
- [EY08126]
- [EY07135]
- [EY015130]
- [EY017011]
Collectively, angiogenic ocular conditions represent the leading cause of irreversible vision loss in developed countries. In the US, for example, retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration are the principal causes of blindness in the infant, working age and elderly populations, respectively. Evidence suggests that vascular endothelial growth factor (VEGF), a 40kDa dimeric glycoprotein, promotes angiogenesis in each of these conditions, making it a highly significant therapeutic target. However, VEGF is pleiotropic, affecting a broad spectrum of endothelial, neuronal and glial behaviors, and confounding the validity of anti-VEGF strategies, particularly under chronic disease conditions. In fact, among other functions VEGF can influence cell proliferation, cell migration, proteolysis, cell survival and vessel permeability in a wide variety of biological contexts. This article will describe the roles played by VEGF in the pathogenesis of retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration. The potential disadvantages of inhibiting VEGF will be discussed, as will the rationales for targeting other VEGF-related modulators of angiogenesis. (C) 2008 Elsevier Ltd. All rights reserved.
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